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human multi-organ tissue microarray  (Biomax Inc)

 
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    Biomax Inc human multi-organ tissue microarray
    Human Multi Organ Tissue Microarray, supplied by Biomax Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+multi-organ+tissue+microarray/human+crc+tissue+microarray+co992/pm35479410-241-0-4
    Average 90 stars, based on 1 article reviews
    human multi-organ tissue microarray - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Microarray:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Recombinant:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    MTT Assay:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Expressing:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Immunohistochemistry:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Staining:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Software:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Comparison:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Derivative Assay:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Multiplexing:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Western Blot:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Control:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Virus:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Plasmid Preparation:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    shRNA:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Saline:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Protease Inhibitor:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Bicinchoninic Acid Protein Assay:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Glutathione Assay:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Enzyme-linked Immunosorbent Assay:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Gene Expression:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Isolation:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Biomarker Discovery:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Membrane:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Sterility:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.

    Transfection:

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer.
    Article Snippet: Human multi-organ tissue microarray Biomax (www.biomax.us/) Cat# BN243c Human pancreatic cancer tissue microarray Biomax (www.biomax.us/) Cat# PA1921a Chemicals, peptides, and recombinant proteins DMEM Corning Cat# 10-013-CV Opti-MEM Thermo Fisher Scientific Cat# 31985-070 Stellate Cell Medium ScienCell Research Laboratories Cat# 5301 Stellate Cell Growth Supplement ScienCell Research Laboratories Cat# 5352 Pancreatic CAF Maintenance Medium Vitro Biopharma Cat# PC00B5 DPBS Corning Cat# 21-030-CV Fetal Bovine Serum Sigma-Aldrich Cat# F2442 Penicillin Streptomycin Solution Corning Cat# 30-002-Cl 0.25% Trypsin EDTA Corning Cat# 25-053-Cl Dimethyl sulfoxide Sigma-Aldrich Cat# D2650 Lipofectamine 3000 Thermo Fisher Scientific Cat# L3000-008 Thiazolyl Blue Tetrazolium Bromide (MTT) Sigma-Aldrich Cat# M5655 Hexadimethrine bromide (Polybrene) Sigma-Aldrich Cat# H9268 L-Glutathione reduced (GSH) Sigma-Aldrich Cat# G6013 L-Glutathione oxidized (GSSG) Sigma-Aldrich Cat# G4376 D-Fructose 1,6-bisphosphate Sigma-Aldrich Cat# F6803 Glutaric acid Sigma-Aldrich Cat# G3407 Taurine Sigma-Aldrich Cat# T0625 L-Ascorbic acid (Vitamin C) Sigma-Aldrich Cat# A92902 L-carnitine hydrochloride Sigma-Aldrich Cat# C0283 Carbocysteine Sigma-Aldrich Cat# C7757 N1-acetylspermidine Sigma-Aldrich Cat# 01467 (Continued on next page) iScience 25, 104193, May 20, 2022 23

    Article Title: EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
    Article Snippet: Human multi-organ tissue microarray , Biomax ( www.biomax.us/ ) , Cat# BN243c.



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    Expression of SORT1 in ovarian healthy and tumoral tissues. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in ovarian tumors. With the immunohistochemical (IHC) scoring system used, the level of expressed SORT1 ranged from 0 to a maximum of 12. ( A ) Representative SORT1 staining by IHC in ovarian healthy, primary and metastases biopsies. Nuclei are stained blue with hematoxylin. Arrows point to ovarian healthy epithelia. Black bars represent 50 µm. ( B ) IHC scores from healthy tissues ( n = 20), benign tumors ( n = 18), malignant tumors ( n = 45) and metastases ( n = 10). ( C ) RT-qPCR was used to quantify the transcript levels of SORT1 in healthy and cancerous ovarian tissues. The SORT1 transcript levels in tumor samples were segregated according to tumor grade and then compared to the values from healthy ovarian tissues. n = 8 for healthy and for Grade I tumor samples, n = 9 for Grade II, n = 17 for Grade III and n = 7 for Grade IV tumor samples. ( D ) The mean IHC scores for SORT1 is shown for healthy ovarian tissue ( n = 20), benign tumors ( n = 18), LGSC ( n = 21), HGSC ( n = 6), CCC ( n = 5), MC ( n = 3), EC ( n = 13), TCC ( n = 5) and GC and NE ( n = 20). All scatter plots include lines showing the means ± SEM, and where each point represents an individual tissue sample.

    Journal: Cancers

    Article Title: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers

    doi: 10.3390/cancers14081877

    Figure Lengend Snippet: Expression of SORT1 in ovarian healthy and tumoral tissues. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in ovarian tumors. With the immunohistochemical (IHC) scoring system used, the level of expressed SORT1 ranged from 0 to a maximum of 12. ( A ) Representative SORT1 staining by IHC in ovarian healthy, primary and metastases biopsies. Nuclei are stained blue with hematoxylin. Arrows point to ovarian healthy epithelia. Black bars represent 50 µm. ( B ) IHC scores from healthy tissues ( n = 20), benign tumors ( n = 18), malignant tumors ( n = 45) and metastases ( n = 10). ( C ) RT-qPCR was used to quantify the transcript levels of SORT1 in healthy and cancerous ovarian tissues. The SORT1 transcript levels in tumor samples were segregated according to tumor grade and then compared to the values from healthy ovarian tissues. n = 8 for healthy and for Grade I tumor samples, n = 9 for Grade II, n = 17 for Grade III and n = 7 for Grade IV tumor samples. ( D ) The mean IHC scores for SORT1 is shown for healthy ovarian tissue ( n = 20), benign tumors ( n = 18), LGSC ( n = 21), HGSC ( n = 6), CCC ( n = 5), MC ( n = 3), EC ( n = 13), TCC ( n = 5) and GC and NE ( n = 20). All scatter plots include lines showing the means ± SEM, and where each point represents an individual tissue sample.

    Article Snippet: The tissue microarrays (#NBP2-30170 for normal tissues, #NBP2-30290 for ovarian cancers and #NBP2-30330 for diverse cancers) were purchased from Novus Biologicals (Toronto, ON, Canada).

    Techniques: Expressing, Immunohistochemical staining, Staining, Quantitative RT-PCR

    Expression of SORT1 in endometrial healthy tissues and endometrial tumor biopsies. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in endometrial tumors. ( A ) Representative SORT1 staining by IHC in endometrial healthy tissue and endometrial tumor biopsies. Nuclei are stained blue with hematoxylin. Black bars represent 50 µm. ( B ) SORT1 IHC scores between healthy endometrial tissues ( n = 2) and endometrial cancerous tissues ( n = 12). Scatter plot include lines showing the means ± SEM, and where each point represents an individual tissue sample.

    Journal: Cancers

    Article Title: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers

    doi: 10.3390/cancers14081877

    Figure Lengend Snippet: Expression of SORT1 in endometrial healthy tissues and endometrial tumor biopsies. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in endometrial tumors. ( A ) Representative SORT1 staining by IHC in endometrial healthy tissue and endometrial tumor biopsies. Nuclei are stained blue with hematoxylin. Black bars represent 50 µm. ( B ) SORT1 IHC scores between healthy endometrial tissues ( n = 2) and endometrial cancerous tissues ( n = 12). Scatter plot include lines showing the means ± SEM, and where each point represents an individual tissue sample.

    Article Snippet: The tissue microarrays (#NBP2-30170 for normal tissues, #NBP2-30290 for ovarian cancers and #NBP2-30330 for diverse cancers) were purchased from Novus Biologicals (Toronto, ON, Canada).

    Techniques: Expressing, Immunohistochemical staining, Staining